1、个人简历

李干武，男，博士，研究员，博士生导师，美国爱荷华州立大学副教授，重要人兽共患病与烈性外来病团队成员；主要从事病原菌致病机理、流行病学、检测与诊断等方面的研究；多年来，在PLoS Pathogens，Journal of Proteomics、Infection and Immunity 和Microbiology等国际主流杂志上发表了30多篇高水平文章，并受邀为PLoS Pathogens、Infection and Immunity 和Microbiology等10多种国际主流杂志审稿；主持或参加了美国NIH、USDA基金项目和中国国家自然科学基金面上项目及重点基础研发计划项目（973计划）；参编美国微生物协会（ASM）出版着作1部，获得德国专利1项；以导师身份培养中、美博士、硕士生多名。

 

2、联系方式

（1）研究方向：兽医微生物及其分子生物学

（2）电话：18348559748

（3）邮箱：liganwu@caas.cn

（4）所在单位：保定市金诺兽药研究所

（5）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

 

3、教育经历

1989.09-1994.06  南京农业大学  兽医学  学士

1996.09-1999.06  南京农业大学  预防兽医学  硕士

2000.09-2005.06  德国柏林自由大学  微生物与动物传染病学   博士

 

4、工作经历

2013年至今             美国爱荷华州立大学   兽医学院助理教授

2009.10-2013.09  美国爱荷华州立大学   兽医学院科研助理教授

2007.08-2009.09  美国爱荷华州立大学   兽医学院博士后

2005.11-2007.07  德国柏林自由大学      博士后

1994.08-1996.07  湖南省畜牧兽医研究所

 

5、承担项目

   1. 国家自然科学基金：尿道致病性大肠杆菌新型双组份信号系统KguS/KguR 控制的毒力岛的调控机制、生物学功能和致病机制（31470243，2015-2018），主持。

   2. 973项目：重要病原细菌关键生物学特性适应性进化机制的研究子课题（2015-2019），参与。

   3.哈尔滨兽医研究所特聘研究员启动基金（2017-2020），主持。

   4.中央高校基本科研经费：南京农业大学引进人才启动基金（2014-2018），主持。

 

6、代表论文与着作

1.Fengwei Jiang, Zuowei Wu, Ying Zheng, Timothy S. Frana, Orhan Sahin, Qijing Zhang, and Ganwu Li*. Genotypes and Antimicrobial Susceptibility Profiles of Hemolytic Escherichia coli from Diarrheic Piglets. Foodborne Pathogens and Disease. 2019 16(2): 94-103.

2.Jiale Ma, Chunxia An, Fengwei Jiang, Huochun Yao, Catherine Logue, Lisa K. Nolan, Ganwu Li*. Extraintestinal pathogenic Escherichia coli increase extracytoplasmic polysaccharide biosynthesis for serum resistance in response to bloodstream signals. Molecular Microbiology. 2018 110(5): 689-706.

3.Bailey Arruda, Paulo Arruda, Melissa Hensch, Qi Chen, Ying Zheng, Chenghuai Yang, Igor Renan Honorato Gatto, Franco Matias Ferreyra, Phil Gauger, Kent Schwartz, Laura Bradner, Karen Harmon, Ben Hause, and Ganwu Li. Porcine Astrovirus Type 3 in Central Nervous System of Swine with Polioencephalomyelitis. Emerg Infect Dis. 2017 Dec;23(12):2097-2100.

4.Bryon A. Nicholson, Aaron C. West, Paul Mangiamele, Nicolle Barbieri, Yvonne Wannemuehler, Lisa K. Nolan, Catherine M. Logue, Ganwu Li*. Genetic Characterization of ExPEC-Like Virulence Plasmids among a Subset of NMEC. PLoS One. 2016 Jan 22;11(1):e0147757.

5.Fengwei Jiang, Chunxia An, YinliBao, Xuefeng Zhao, Robert L. Jernigan, Andrew Lithio, Daniel Nettleton, Ling Li, Eve SyrkinWurtele, Lisa K. Nolan, Chengping Lu, and Ganwu Li*: ArcA Controls Metabolism, Chemotaxis and Motile Contributing to the Pathogenicity of Avian Pathogenic E. coli. Infection and Immunity. 2015 Sep; 83(9): 3545-54.

6.Nicolle L. Barbieri, Bryon Nicholson, Ashraf Hussein, WentongCai, Yvonne M. Wannemuehler, Giuseppe Dell'Anna, Catherine M. Logue, Fabiana Horn, Lisa K. Nolan, and Ganwu Li*: FNR Regulates the Expression of Important Virulence Factors Contributing to the Pathogenicity of UropathogenicEscherichia coli. Infection and Immunity. 2014 Dec; 82(12):5086-98. doi: 10.1128/IAI.02315-14.

7.Wentong Cai, Yvonne Wannemuehler, Giuseppe Dell'Anna, Bryon Nicholson, Nicolle L. Barbieri, Subhashinie Kariyawasam, Yaping Feng, Catherine M. Logue, Lisa K. Nolan, Ganwu Li*: A Novel Two-Component Signaling System Facilitates Uropathogenic Escherichia coli’s Ability to Exploit Abundant Host Metabolites. PLoS Pathogens 2013, 9(6): e1003428. doi:10.1371/journal.ppat.1003428

8.Jianqiang Zhang, Ying Zheng, Xiaoqin Xia, Qi Chen, Sarah A. Bade, Kyoung-Jin Yoon, Karen M. Harmon, Phillip C. Gauger, Rodger G. Main, and Ganwu Li*. Whole Genome Sequencing of Porcine Reproductive and Respiratory Syndrome Virus from Cell Culture Isolates and Clinical Samples Using Next-Generation Sequencing Technology. Journal of Veterinary Diagnostic Investigation. 2017 Jan; 29(1): 41-50. doi: 10.1177/1040638716673404

9.Bryon Nicholson, Aaron C. West, Paul Mangiamele, Nicolle Barbieri, Kathy Mou, Yvonne Wannemuehler, Lisa K. Nolan, Catherine M. Logue and Ganwu Li*. Genetic Characterization of ExPEC-like Virulence Plasmids among a Subset of NMEC. PLoS One, 2016 Jan 22; 11(1):e0147757. doi: 10.1371/journal.pone.0147757.

10.Ganwu Li, WentongCai, Ashraf Hussein, Yvonne Wannemuheler, Catherine M. Logue, and Lisa K Nolan: Proteome response of a zoonotic ExPEC to human and avian sera. Journal of Proteomics, 2012; 75 (15): 4853-62.

11.Ganwu Li, Kelly Tivendale, Peng Liu, Yaping Feng, Yvonne Wannemuheler, WentongCai, Paul Mangiamele, Timothy J. Johnson, Chaeles W. Penn, and Lisa K Nolan: Transcriptome Analysis of Avian Pathogenic Escherichia coli in Chicken Serum Reveals Adaptive Responses to Systemic Infection. Infection and Immunity, 2011, 79 (5): 1951-1960.

12.Ganwu Li, Yaping Feng, SubhashinieKariyawasam, Kelly A. Tivendale, Yvonne Wannemuehler, Fanghong Zhou, Catherine M. Logue and Lisa K. Nolan: AatA is a Novel Autotransporter and Virulence Factor of Avian Pathogenic Escherichia coli. Infection and Immunity, 2010, 78(3): 898-906.

13.Ganwu Li, Claudia Laturnus, Christa Ewers, Lothar H. Wieler: Identification of Genes Required for Avian E. coli-Septicaemia by Signature-tagged Mutagenesis.  Infection and Immunity, 2005, 73: 2818-2827.

 

7、专利和标准

1．Esther-Maria Antao, Li Ganwu, Lothar Wieler, Rudolf Preisinger, Christa Ewers. Identification and characterization of a novel avian pathogenic E. coli (APEC) fimbrialadhesin. Publication number: EP2298798, Application number: EP20100176013, Mar 23, 2011, Europe patent.

 

（2019年6月更新）