温志远，男，博士，副研究员，硕士生导师。重要人兽共患病与烈性外来病团队。研究方向为狂犬病感染与免疫机制及防控研究及烈性外来人兽共患病防控研究。主要从事狂犬病毒的感染入侵机制研究，及烈性外来病防控和致病机制研究。作为主持人和主要执行人参与了国家自然科学基金，国家支撑计划项目、科技部国际合作专项等10余项科研项目。主要参与研制了我国具有完全自主知识产权的新城疫-禽流感重组二联活疫苗。发表SCI文章26篇，其中第一作者或通讯作者10篇。获得国家发明专利2项。

 

（1）研究方向：动物疫苗与分子免疫学

（2）电话：0451-51051725

（3）邮箱：wenzhiyuan@caas.cn

（4）通讯地址：哈尔滨市香坊区哈平路678号

 

1999.09-2003.06  内蒙古农业大学      动物医学专业                学士

2003.09-2006.06  内蒙古农业大学      预防兽医学专业              硕士

2006.09-2009.06  保定市金诺兽药研究所  预防兽医学专业  博士

2007.02-2009.03  美国Emory大学医学院  微生物学与免疫学专业  联合培养博士

 

2009.06-2014.12      中国农科院哈尔滨兽医研究所 助理研究员

2014.12- 今          中国农科院哈尔滨兽医研究所 副研究员

 

   1. 兽医生物技术国家重点实验室课题：利用siRNA技术筛选狂犬病病毒复制感染相关宿主因子，111万元； 

   2. “十二五”国家科技支撑计划课题：严重威胁的外来动物疫病免疫防控储备技术，588万元；

 

1.Liu RQ, Ge JY, Wang JL, Shao Y, Zhang HL, Wang JL, Wen ZY*, Bu ZG. 2017. Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels. Journal of Integrative Agriculture 16:2264-2273.

2.Liu R, Wen Z*, Wang J, Ge J, Chen H, Bu Z. 2015. Absence of Middle East respiratory syndrome coronavirus in Bactrian camels in the West Inner Mongolia Autonomous Region of China: surveillance study results from July 2015. Emerg Microbes Infect 4:e73.

3.Wen Z, Zhao B, Song K, Hu X, Chen W, Kong D, Ge J, Bu Z. 2013. Recombinant lentogenic Newcastle disease virus expressing Ebola virus GP infects cells independently of exogenous trypsin and uses macropinocytosis as the major pathway for cell entry. Virol J 10:331.

4.Kong D, Wen Z*, Su H, Ge J, Chen W, Wang X, Wu C, Yang C, Chen H, Bu Z. 2012. Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Virology 432:327-335.

5.Wen Z, Wang X, Dong K, Zhang H, Bu Z, Ye L, Yang C. 2017. Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice. Microbes Infect doi:10.1016/j.micinf.2017.08.013.

6.Shuai L, Wang X, Wen Z, Ge J, Wang J, Zhao D, Bu Z. 2017. Genetically modified rabies virus-vectored Ebola virus disease vaccines are safe and induce efficacious immune responses in mice and dogs. Antiviral Res 146:36-44.

7.Chen W, Wen Z, Zhang J, Li C, Huang K, Bu Z. 2017. Establishing a Safe, Rapid, Convenient and Low-cost Antiviral Assay of Interferon Bioactivity Based on Recombinant VSV Expressing GFP. J Virol Methods doi:10.1016/j.jviromet.2017.08.007.

8.Zhang M, Ge J, Li X, Chen W, Wang X, Wen Z*, Bu Z. 2016. Protective efficacy of a recombinant Newcastle disease virus expressing glycoprotein of vesicular stomatitis virus in mice. Virol J 13:31.

9.Wang J, Yang J, Ge J, Hua R, Liu R, Li X, Wang X, Shao Y, Sun E, Wu D, Qin C, Wen Z*, Bu Z. 2016. Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry. Virol J 13:109.

10.Shi J, Wen Z, Guo J, Zhang Y, Deng G, Shu Y, Wang D, Jiang Y, Kawaoka Y, Bu Z, Chen H. 2012. Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice. Antiviral Res 93:346-353.

11.Wen Z, Ye L, Gao Y, Pan L, Dong K, Bu Z, Compans RW, Yang C. 2009. Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge. Antiviral Res 84:215-224.

12.Sun Y, Carrion R, Jr., Ye L, Wen Z, Ro YT, Brasky K, Ticer AE, Schwegler EE, Patterson JL, Compans RW, Yang C. 2009. Protection against lethal challenge by Ebola virus-like particles produced in insect cells. Virology 383:12-21.

13.Ge J, Deng G, Wen Z, Tian G, Wang Y, Shi J, Wang X, Li Y, Hu S, Jiang Y, Yang C, Yu K, Bu Z, Chen H. 2007. Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. Journal of virology 81:150-158.

14.Zhu Q, Zarnitsyn VG, Ye L, Wen Z, Gao Y, Pan L, Skountzou I, Gill HS, Prausnitz MR, Yang C, Compans RW. 2009. Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge. Proc Natl Acad Sci U S A 106:7968-7973.

   

   1. 步志高，温志远，葛金英，表达尼帕脑炎病毒F蛋白的重组新城疫病毒LaSota疫苗株， ZL201110431892.7

   2. 步志高，温志远，葛金英，表达尼帕脑炎病毒G蛋白的重组新城疫病毒LaSota疫苗株， ZL201110431883.8