孙元，男，博士，副研究员，硕士生导师，保定市金诺兽药研究所猪烈性传染病创新团队骨干二级。

主持国家自然科学基金面上项目1项，青年项目1项；十三五国家重点研发计划项目子课题1项；哈尔滨市科技创新人才专项资金项目1项。获国家发明专利3项（排名第2），获转基因微生物安全证书2项（排名第2）。以第一/共第一作者或通讯/共通讯作者发表SCI文章20篇，影响因子累计达52.52，单篇最高影响因子为4.606。

 

（1）研究方向：动物疫苗与分子免疫学

（2）电话：13945100699

（3）邮箱：sunyuan@caas.cn

（4）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

 

1998.09 - 2003.06  东北农业大学  动物医学  学士学位

2003.09 - 2006.06  中国农业科学院兰州兽医研究所  预防兽医学  硕士学位

2009.09 - 2012.06  中国农业科学院兰州兽医研究所  预防兽医学  博士学位

 

2013.12 – 至今   保定市金诺兽药研究所  副研究员

2009.12 - 2013.11  保定市金诺兽药研究所 助理研究员

2006.17 - 2009.11  保定市金诺兽药研究所 研究实习员

 

1. 国家自然科学基金面上项目：伪狂犬病病毒变异株神经毒力增强的分子机制（31570149，2016.01-2020.12），77万元；

2. 国家重点研发计划项目子课题：伪狂犬病病毒经典株、变异株毒力基因的鉴定及致病力差异的分子基础（2016YFD0500100，2016.07-2020.12），115万元；

3. 国家自然科学基金青年基金项目：伪狂犬病病毒/日本脑炎病毒复制子嵌合疫苗载体的构建及评价.（31200690，2013.01-2015.12），25万元；

4. 2014年哈尔滨市科技创新人才专项资金项目-青年后备人才计划：伪狂犬病病毒变异株载体猪瘟疫苗的研制（2014RFQYJ126，2014.06-2016.06），4万元。

 

1.  Li LF, Yu J, Zhang Y, Yang Q, Li Y, Zhang L, Wang J, Li S, Luo Y, Sun Y*, Qiu HJ*. Interferon-inducible oligoadenylate synthetase-like protein acts as an antiviral effector against classical swine fever virus via the MDA5-mediated type I interferon signaling pathway. J Virol, 2017, 91(11): e01514-16.

2.  Luo Y, Ji S, Lei JL, Xiang GT, Liu Y, Gao Y, Meng XY, Zheng G, Zhang EY, Wang Y, Du ML, Li Y, Li S, He XJ, Sun Y*, Qiu HJ*. Efficacy evaluation of the C-strain-based vaccines against the subgenotype 2.1d classical swine fever virus emerging in China. Vet Microbiol. 2017, 201:154-161. 

3.  Sun Y, Luo Y, Wang CH, Yuan J, Li N, Song K, Qiu HJ. Control of swine pseudorabies in China: Opportunities and limitations. Vet Microbiol. 2016, 183:119-124.

4.  Xia SL, Du M, Lei JL, Liu Y, Wang Y, Ji S, Xiang GT, Li LF, Cong X, Luo Y, Shao L, Qiu HJ*, Sun Y*.  Piglets with maternally derived antibodies from sows immunized with rAdV-SFV-E2 were completely protected against lethal CSFV challenge. Vet Microbiol. 2016, 190:38-42. 

5.  Xia SL, Lei JL, Du M, Wang Y, Cong X, Xiang GT, Li LF, Yu S, Du E, Liu S, Sun Y*, Qiu HJ*. Enhanced protective immunity of the chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever in pigs by a Salmonella bacterial ghost adjuvant. Veterinary research. 2016, 47:64. 

6.  Xia SL, Xiang GT, Lei JL, Du M, Wang Y, Zhou M, Liu Y, Ji S, Wang YL, Luo Y, Sun Y*, Qiu HJ*. Efficacy of the marker vaccine rAdV-SFV-E2 against classical swine fever in the presence of maternally derived antibodies to rAdV-SFV-E2 or C-strain. Vet Microbiol. 2016, 196:50-54. 

7.  Lei JL, Xia SL, Wang Y, Du M, Xiang GT, Cong X, Luo Y, Li LF, Zhang L, Yu J, Hu Y, Qiu HJ*, Sun Y*. Safety and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs. Immunology letters. 2016, 174:63-71. 

8.  Cong X, Lei JL, Xia SL, Wang YM, Li Y, Li S, Luo Y, Sun Y*, Qiu HJ*. Pathogenicity and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant in susceptible animals. Vet Microbiol. 2016, 182:170-177. 

9.  Wang Y, Xia SL, Lei JL, Cong X, Xiang GT, Luo Y, Sun Y*, Qiu HJ*. Dose-dependent pathogenicity of a pseudorabies virus variant in pigs inoculated via intranasal route. Veterinary immunology and immunopathology. 2015, 168:147-152. 

10.  Wang Y, Yuan J, Cong X, Qin HY, Wang CH, Li Y, Li S, Luo Y, Sun Y*, Qiu HJ*. Generation and Efficacy Evaluation of a Recombinant Pseudorabies Virus Variant Expressing the E2 Protein of Classical Swine Fever Virus in Pigs. Clinical and vaccine immunology. 2015, 22:1121-1129.  

11.  Luo Y, Li L, Austermann-Busch S, Dong M, Xu J, Shao L, Lei J, Li N, He WR, Zhao B, Li S, Li Y, Liu L, Becher P, Sun Y*, Qiu HJ*. Enhanced expression of the Erns protein of classical swine fever virus in yeast and its application in an indirect enzyme-linked immunosorbent assay for antibody differentiation of infected from vaccinated animals. Journal of virological methods. 2015, 222:22-27.

12.  Luo Y, Li N, Cong X, Wang CH, Du M, Li L, Zhao B, Yuan J, Liu DD, Li S, Li Y, Sun Y*, Qiu HJ*. Pathogenicity and genomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China. Vet Microbiol. 2014, 174:107-115. 

13.  Wang CH, Yuan J, Qin HY, Luo Y, Cong X, Li Y, Chen J, Li S, Sun Y*, Qiu HJ*.  A novel gE-deleted pseudorabies virus (PRV) provides rapid and complete protection from lethal challenge with the PRV variant emerging in Bartha-K61-vaccinated swine population in China. Vaccine. 2014, 32:3379-3385. 

14.  Sun Y, Tian DY, Li S, Meng QL, Zhao BB, Li Y, Li D, Ling LJ, Liao YJ, Qiu HJ. Comprehensive evaluation of the adenovirus/alphavirus-replicon chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever. Vaccine. 2013, 31:538-544. 

15.  Sun Y, Li HY, Tian DY, Han QY, Zhang X, Li N, Qiu HJ. A novel alphavirus replicon-vectored vaccine delivered by adenovirus induces sterile immunity against classical swine fever. Vaccine. 2011, 29:8364-8372.

 

1. 仇华吉，孙元，适应无血清培养的HEK293细胞系及其应用，ZL201210071586.1；

2. 仇华吉，孙元，李娜，李宏宇，腺病毒/甲病毒复制子嵌合载体猪瘟疫苗及其应用，ZL201010297576.0；

3. 仇华吉，孙元，罗玉子，李素，李永锋，伪狂犬病病毒变异株双基因缺失毒株及其构建方法和应用，ZL201410105058.2；

4. 仇华吉，李永锋，孙元，李素，罗玉子，绿色荧光蛋白标记的重组病毒及其拯救方法和应用，ZL201310069486.X；

5. 仇华吉，张兴娟，孙元，刘大飞，用于可视化检测猪瘟病毒野毒株的RT-LAMP引物-2012-lamp，ZL200910180317.7；