2、联系方式

（1）研究领域：动物细菌病

（2）研究方向：奶牛乳房炎防治及抗耐药菌新药研究

（3）电话：0451-51056734

（4）邮箱：huaxin@caas.cn

（5） 通讯地址：黑龙江省哈尔滨市香坊区哈平路678号哈尔滨兽医研究所综合楼5008，150069

 

3、教育经历 

2003.09－2007.07   中国药科大学                    药学     学士

2008.09－2014.07   东北林业大学                    植物学   博士

2012.10－2013.10   美国德克萨斯州立大学奥斯汀分校  药学     联合培养博士

 

4、工作经历

2007.09－2012.09    浙江海正药业有限公司           产品研发专员

2014.07－2016.12    中国农科院哈尔滨兽医研究所     助理研究员

2014.07至今        中国农科院哈尔滨兽医研究所     博士后

2014.07至今        中国农科院哈尔滨兽医研究所     副研究员

 

5、承担项目

1)国家自然科学基金青年基金项目：香鳞毛蕨素抗甲氧西林耐药金黄色葡萄球菌分子作用机制研究（31602100，2017.01-2019.12），21万元。

2)中国博士后科学基金：香鳞毛蕨单体活性成分的抗MRSA分子机制研究（2016M591311，2016.06-2018.06），5万元。 

3)黑龙江省科学基金面上项目：木豆叶抗奶牛源MRSA活性成分筛选及其抗菌机制研究（C2016063，2016.06-2019.06），6万元。

4)中央级公益性科研院所基本科研业务费项目：甲氧西林耐药金黄色葡萄球菌抗菌新药创制（1610302017007，2017.01-2017.12），66万元。

5)中央级公益性科研院所基本科研业务费项目：抗耐药菌中草药活性成分筛选及其抗菌机理研究（SKLVBP201434-3，2014.01-2014.12），4万元。

 

6、代表论文与着作

1)Hua Xin, Fu YJ, Zu YG, Wu N, Kong Y, Li J, Peng X, and Efferth T. Plasma pharmacokinetics and tissue distribution study of cajaninstilbene acid in rats by liquid chromatography with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2010, 52:273-279.

2)Hua Xin, Fu YJ, Zu YG, Zhang L, Wang W, and Luo M. Determination of pinostrobin in rat plasma by LC-MS/MS: application to pharmacokinetics. Journal of Pharmaceutical and Biomedical Analysis. 2011, 56:841-845.

3)Hua Xin, Peng X, Tan S, Li C, Wang W, Luo M, Fu Y, Zu Y, and Smyth H. In vitro oxidative metabolism of cajaninstilbene Acid by human liver microsomes and hepatocytes: involvement of cytochrome p450 reaction phenotyping, inhibition, and induction studies. Journal of Agricultural and Food Chemistry. 2014, 62:10604-10614.

4)Hua Xin, Tan S, Bandara HM, Fu Y, Liu S, and Smyth HD. Externally controlled triggered-release of drug from PLGA micro and nanoparticles. PLoS One. 2014, 9: e114271.

5)Hua Xin, Yang Q, Dong Z, Zhang J, Zhang W, Wang Q, Tan S, and Smyth HD. Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment. Drug Delivery. 2017, 24:511-518.

6)Tan S, Dong Z, Zhang J, Efferth T, Fu Y, and Hua Xin*. Cytochrome P450 reaction phenotyping and inhibition and induction studies of pinostrobin in human liver microsomes and hepatocytes. Biomedical Chromatography. 2017, 31(6):e3888..

7)Si H, Zhang WJ, Chu S, Wang XM, Dai L, Hua Xin, Dong Z, Schwarz S, and Liu S. Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin. Antimicrobial Agents and Chemotherapy. 2015, 59:7113-7116.

8)Jiang SG, Zu YG, Zhang L, Fu YJ, Zhang Y, Wang Z, Hua Xin, and Wang JT. Determination of a hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel in rat plasma by LC-MS/MS. Biomedical Chromatography. 2009, 23:472-479.

9)Wan D, Jiang C, Hua Xin, Wang T, and Chai Y. Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells. Anticancer Drugs. 2015, 26(9):931-941.

10)Wang XM, Dong Z, Schwarz S, Zhu Y, Hua Xin, Zhang Y, Liu S, and Zhang WJ. Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene fosA3 among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China. Antimicrobial Agents and Chemotherapy. 2017, 61(9):e00859.

11)Yuan X, Liu Y, Hua Xin, Deng X, Sun P, Yu C, Chen L, Yu S, Liu S, and Pang H. Myricetin ameliorates the symptoms of collagen-induced arthritis in mice by inhibiting cathepsin K activity. Immunopharmacology and Immunotoxicology. 2015,37:513-519.

12)Zhang WJ, Wang XM, Dai L, Hua Xin, Dong Z, Schwarz S, and Liu S. Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-beta-lactamase gene blaCTX-M-14b. Antimicrobial Agents and Chemotherapy. 2015, 59:1337-1340.

13)Kong Y, Fu YJ, Zu YG, Liu W, Wang W, Hua Xin, and Yang M. Ethanol modified supercritical fluid extraction and antioxidant activity of cajaninstilbene acid and pinostrobin from pigeonpea [Cajanus cajan (L.) Millsp.] leaves. Food Chemistry. 2009, 117:152-159.

 

7、专利和标准

1)付玉杰，祖元刚，张谡，刘威，孔羽，祖柏实，杨梅，顾成波，华 欣. 一种从木豆根茎中提取、分离和纯化染料木素的方法， ZL 200910071470.6；  

2)付玉杰，祖元刚，吴楠，孔羽，刘威，华 欣. 木豆叶中木豆芪酸及球松素在制备抗疱疹病毒药物中的应用，ZL 200910071471.0；

3)付玉杰，李双明，杨刚，吴楠，罗猛，梁璐，陈晓亮，李政楠，刘霞，吴晓敏，华欣. 一种多西紫杉醇新衍生物的合成方法及其在制备抗肿瘤药物中的应用，ZL 201010184472.9。

 

8、获得奖励

1)荣获2017年度中国农业科学院优秀博士后称号，2017。