保定市金诺兽药研究所

1、个人简历

翁长江，男，博士，研究员，博士生导师，基础免疫团队首席科学家。长期从事猪繁殖与呼吸综合征病毒、猪脑心肌炎病毒等诱导天然免疫和炎症反应的研究。近年来，先后主持国家自然科学基金委面上项目，中国农业科学院重大项目培育项目及中国农业科学院创新工程基金等项目。在Nature，Cell Stem Cell，PNAS，Oncogene，Cancer Research，Journal of Virology, Journal of Immunology和Journal of Biological Chemistry等专业杂志发表科技论文20多篇，被国际同行引用500多次。全国农业生化与分子生物学理事。获得中华农业科技奖一项。

2、联系方式

（1）研究方向：兽医微生物及其分子生物学

（2）电话：0451-51051756

（3）邮箱：wengchji@163.com

（4）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

3、教育经历

1991.09–1994.07 长江大学畜牧兽医专业专科

1996.09–1999.07 华中农业大学兽医微生物与免疫专业硕士

2000.07–2005.10 中国科学院微生物专业博士

4、工作经历

2005/10-2008/10 美国Stowers Institute 博士后

2008/10-2010/10 美国加州大学旧金山分校博士后

2010/10-至今保定市金诺兽药研究所基础免疫创新团队首席科学家

5、承担项目

(1)国家自然科学基金面上项目：免疫球蛋白lambda 链及其相似肽抑制I型干扰素产生的分子机制及促进PRRSV复制的研究（31640083，2017.01-2017.12），15万元；

(2)国家自然科学基金面上项目： PRRSV编码蛋白与宿主蛋白相互作用的研究（31172333，2012.01-2015.12），57万元；

(3)国家自然科学基金青年基金：猪繁殖与呼吸综合征病毒NSP1β与HSP40相互作用抑制I型干扰素的产生及其分子机制（31302163，2014.01-2016.12），25万元；

(4)国家自然科学基金面上项目：PRRSV 编码蛋白与宿主蛋白相互作用的研究（31172333，2012.01-2015.12），50万元。

(5)中国农业科学院重大项目培育项目：重要动物病毒在巨噬细胞中复制及调控天然免疫机制的研究（2013ZL034，2013.01-2013.12），80万元。

6、代表论文与着作

1.Jiangnan Li, Shengnan Wang, Changyao Li, Wang C, Yonggang Liu, Gang Wang, Xijun He, Liang Hu, Liu Y, Mengmeng Cui, Caihong Bi, Zengyu Shao, Xiaojie Wang, Tao Xiong, Xuehui Cai*, Li Huang*, Changjiang Weng*. Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses. Vet Microbiol. 2017 May; 204:35-42.

2.Li Huang, Tao Xiong, Huibing Yu, Qian Zhang, Kuili Zhang, Changyao Li, Liang Hu, Yuanfeng Zhang, Lijie Zhang, Qingfang Liu, Wang S, He X, Zhigao Bu, Xuehui Cai, Shangjin Cui*, Jiangnan Li*, Changjiang Weng*. Encephalomyocarditis Virus 3C Protease Attenuates Type I Interferon Production through Disrupting TANK-TBK1-IKKε-IRF3 Complex. Biochem J. 2017 Jun 9;474(12):2051-2065.

3.Li Hu, Xueyuan Li, Qingfang Liu, Xu J, Ge H, Wang Z, Wang H, Zhe Wang, Shi C, Xinzhi Xu X, Huang J, Zhiguo Lin*, Pieper RO*, Changjiang Weng*. UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Oncogene. 2017 Feb 23;36(8):1145-1156.

4.Jiangnan Li, Yuanyuan Liu, Liang Hu, Li Huang, Yang Mu, Xuehui Cai, Changjiang Weng*. DDX19A Senses Viral RNA and Mediates NLRP3-dependent Inflammasome Activation. J Immunol. 2015 Dec 15;195(12):5732-49.

5.Li Huang, Qinfang Liu, Lijie Zhang, Quan Zhang, Liang Hu, Changyao Li, Shengnan Wang, Jiangnan Li, Yuanfeng Zhang, Huibin Yu, Yan Wang, Zhaohua Zhong, Tao Xiong, Xueshan Xia, Xiaojun Wang, Li Yu, Guohua Deng, Xuehui Cai, Shangjin Cui*, Changjiang Weng*. Encephalomyocarditis Virus 3C Protease relieves TANK Inhibitory Effect on TRAF6-mediated NF-kappaB Signaling through Cleavage of TANK. J Biol Chem. 2015 Nov 13;290(46):27618-32.

6.Lei Pan, Su Wang, Tinglin Lu, Changjiang Weng, Xiaoqing Song, Joseph K. Park, Jin Sun,Zhi-Hao Yang, Junjing Yu, Hong Tang, Dennis M. McKearin, Daniel A. Chamovitz, Jianquan Ni, Ting Xie*. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014 Oct 9;514(7521):233-6.

7.Jiangnan Li, Dongwei Guo, Li Huang, Manman Yin, Qingfang Liu, Yan Wang, Chunmei Yang, Yuanyuan Liu, Lijie Zhang, Zhijun Tian, Xuehui Cai, Liyun Yu, Changjiang Weng*. The interaction between host Annexin A2 and viral Nsp9 is beneficial for replication of porcine reproductive and respiratory syndrome virus. Virus Res. 2014 Aug 30;189:106-13.

8.Dan Li, Su Li, Yuan Sun, Hong Dong, Yongfeng Li, Bibo Zhao, Dongwei Guo, Changjiang Weng*, Hua-Ji Qiu*. Poly(C)-Binding Protein 1, a Novel Npro interacting Protein Involved in Classical Swine Fever Virus Growth. J Virol. 2013 Feb;87(4):2072-80.

9.Amith Panner, Courtney Crane, Changjiang Weng, Alberto Feletti, Shanna Fang Russell O. Pieper. Ubiquitin-Specific Protease 8 Links the PTEN-Akt-AIP4 Pathway to the Control of FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme. Cancer Res. 2010 Jun 15;70(12):5046-53.

10.Amith Panner, Courtney Crane, Changjiang Weng, Alberto Feletti, Andrew T. Parsa and Russell O. Pieper. A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme. Cancer Res. 2009 Oct 15;69(20):7911-6.

11.Run Shen#, Changjiang Weng#, Junjing Yu, Ting Xie*. eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11623-8.

12.Zhigang Jin, Daniel Kirilly, Changjiang Weng, Eihachiro Kawase, Xiaoqing Song, Sarah Smith, Joel Schwartz and Ting Xie. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell. 2008 Jan 10;2(1):39-49.

13.Lei Pan, Shuyi Chen, Changjiang Weng, Gerald Call, Dongxiao Zhu, Hong Tang, Nian Zhang, and Ting Xie. Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. Cell Stem Cell. 2007 Oct 11;1(4):458-69.

14.Changjiang Weng, Yuan Li, Dan Xu, Yong Shi, and Hong Tang. Specific cleavage of MCL-1 by caspase-3 in TRAIL-induced apoptosis in Jurkat leukemia T cells. J Biol Chem. 2005 Mar 18;280(11):10491-500.