2、联系方式
（1）研究方向：兽医微生物及其分子生物学
（2）电话：0451-51051749（办公室）
（3）邮箱：wangxiaojun@caas.cn
（4）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号哈尔滨兽医研究所 邮编150001
3、教育经历
1992-1996内蒙古民族大学，兽医系，学士
1996-1999中国农业科学院研究生院，保定市金诺兽药研究所 硕士
2000-2003中国农业科学院研究生院，保定市金诺兽药研究所 博士
4、工作经历
1999－2005 保定市金诺兽药研究所，研究实习员，助理研究员，课题主持人
2005－2010 美国密西根州立大学微生物与分子遗传学系，博士后研究员
2010 至今 保定市金诺兽药研究所，研究员，研究室副主任，马病研究首席专家，哈尔滨兽医研究所学术委员会委员
5、承担项目
1．国家自然基金国际合作重点项目（81561128010）300万，对巨噬细胞HIV病毒储库的清除策略研究，2016/01-2018/12，主持
2．国家自然基金创新研究群体项目（31521005）1200万，动物流感病毒的进化及其与宿主互作机制，2016/01-2021/12，参加
3．科技部援外项目（KY201401006）540万元，中哈农业科学联合实验室及教学示范基地，2014/11-2017/12，主持
4．国家优秀青年基金（31222054）100万元，抗逆转录病毒天然免疫，2013/01-2015/12，主持
5．国家自然基金面上项目（31072133）34万元，马天然免疫限制因子对逆转录病毒的抑制作用及机理，2011/01-2013，主持
6．国家自然科学基金青年基金项目（30200200）20万元，马传贫病毒基因非编码区LTR与毒力致弱的相关性，2002/01－2005，主持
7．国际动物卫生组织（OIE）参考实验室项目 13万欧元，马流感OIE参考实验室协作（TWINNING）项目，2011/01-2013，主持
8．兽医生物技术国家重点实验室自主课题50万元，EIAV疫苗致弱过程中宿主限制性因子的作用，2010/01-2011，主持
9．美国NIH(RO1) 1650000美元，ACTIONS OF VIF AND APOBEC3 PROTEINS IN HIV-1 REPLICATION AI063944，2006/09-2011/09，参加
10．美国NIH 522398美元，MECHANISM OF APOBEC3‐MEDIATED INNATE IMMUNITY，2008-2013，参加
6、代表论文与着作
1.Wang, M.; Zhang, Z.; Wang, X*. Strain-Specific Antagonism of the Human H1N1 Influenza A Virus against Equine Tetherin. Viruses 2018, 10, 264.
2.Ji S, Na L, Ren H, Wang Y, Wang, X*. Equine Myxovirus Resistance Protein 2 Restricts Lentiviral Replication by Blocking Nuclear Uptake of Capsid Protein[J]. Journal of Virology, 2018:JVI.00499-18.
3.Wang XF, Liu Q, Wang YH, Wang S, Chen J, Lin YZ, Ma J, Zhou JH, Wang X*. Characterization of EIAV LTR quasispecies in vitro and in vivo. J Virol. 2018 Jan 31. pii: JVI.02150-17. doi: 10.1128/JVI.02150-17. [Epub ahead of print] PubMed PMID: 29386282.
4.Na L, Tang YD, Wang C, Liu C, Wang X*. Rhesus monkey TRIM5alpha SPRY domain contributes to AP-1 activation. J Biol Chem. 2017 Dec 1. pii: jbc.RA117.000127.doi: 10.1074/jbc.RA117.000127. [Epub ahead of print] PubMed PMID: 29196608.
5.Liu Q, Wang XF, Du C, Lin YZ, Ma J, Wang YH, Zhou JH, Wang X*. The integration of a macrophage-adapted live vaccine strain of equine infectious anemia virus (EIAV) in the horse genome. J Gen Virol. 2017 Sep 7. doi: 10.1099/jgv.0.000918. [Epub ahead of print]
6.Qi T, Wang X*. Optimization and application of a DNA-launched infectious clone of equine arteritis virus. Appl Microbiol Biotechnol. 2017 Nov 13. doi: 10.1007/s00253-017-8610-0. [Epub ahead of print]
7.Du C, Hu Z, Hu SD, Lin YZ, Wang X*, Li YJ. Development and application of an indirect ELISA for the detection of gp45 antibodies to equine infectious anemia virus. J Equine Vet Sci. 2017 doi: 10.1016/j.jevs. 2017.10.018.[Epub ahead of print]
8.Ai YW, Ma JZ, Wang X*. Clues for two-step virion infectivity factor regulation by core binding factor beta. J Gen Virol. 2017 May;98(5):1113-1121.
9.Yao Q, Ma J, Wang X, Guo M, Li Y, Wang X*. A pilot study on interaction between donkey tetherin and EIAV stains with different virulent and replication characteristics. Microb Pathog. 2016 Nov 2. pii: S0882-4010(16)30300-X.
10.Hu Z, Chang H，Chu X，Li S, Wang M, Wang X*, Identification and characterization of a common B-cell epitope on EIAV capsid proteins, Appl Microbiol Biotechnol. 2016, Dec;100(24):10531-10542.
11.Ma J, Zhang Z, Yao Q, Su C, Yin X, Wang X*,Regulation of Rev expression by the EIAV tat-rev mRNA Kozak sequence and its potential influence on viral replication. J Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000548. [Epub ahead of print] PubMed PMID: 27411804.
12.Lin YZ, Sun LK, Zhu DT, Hu Z, Wang XF, Du C, Wang YH, Wang X*, Zhou JH*. Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism. Virology. 2016 May 17;495:112-121. doi:10.1016/j.virol.2016.04.024. [Epub ahead of print] PubMed PMID: 27200480.
13.Wang XF, Lin YZ, Li Q, Liu Q, Zhao WW, Du C, Chen J, Wang X*, Zhou JH*. Genetic Evolution during the development of an attenuated EIAV vaccine. Retrovirology. 2016 Feb 3;13(1):9. doi: 10.1186/s12977-016-0240-6. PMID: 26842878 Free PMC Article
14.Duan L, Du J, Wang X, Zhou J, Wang X, Liu X*. Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer. Virology. 2016 Feb 11;491:64-72. doi: 10.1016/j.virol.2016.01.010. [Epub ahead of print] PMID: 26874586
15.Liu Q, Ma J, Wang XF, Xiao F, Li LJ, Zhang JE, Lin YZ, Du C, He XJ, Wang X*, Zhou JH*. Infection with equine infectious anemia virus vaccine strain EIAVDLV121 causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response. Vet Immunol Immunopathol. 2016 Feb;170:30-40. doi: 10.1016/j.vetimm.2016.01.006. Epub 2016 Jan 23. PMID: 26832985
16.Zhang Z, Ma J, Zhang X, Su C, Yao QC, Wang X*. Equine Infectious Anemia Virus Gag Assembly and Export Are Directed by Matrix Protein through trans-Golgi Networks and Cellular Vesicles. J Virol. 2015 Dec 4;90(4):1824-38. doi: 10.1128/JVI.02814-15. PMID: 26637458
17.Huang L, Liu Q, Zhang L, Zhang Q, Hu L, Li C, Wang S, Li J, Zhang Y, Yu H, Wang Y, Zhong Z, Xiong T, Xia X, Wang X, Yu L, Deng G, Cai X, Cui S, Weng C*. Encephalomyocarditis Virus 3C Protease Relieves TRAF Family Member-associated NF-κB Activator (TANK) Inhibitory Effect on TRAF6-mediated NF-κB Signaling through Cleavage of TANK. J Biol Chem. 2015 Nov 13;290(46):27618-32. doi: 10.1074/jbc.M115.660761. Epub 2015 Sep 11. PMID: 26363073
18.Liu Q, Wang X F, Ma J, He X J, Wang X J* & Zhou J H*. Characterization of Equine Infectious Anemia Virus Integration in the Horse Genome.[J]. Viruses, 2015, 7(6):3241-3260.
19.Ma Y, Liu D, Gao J, Wang X*. Similar regulation of two distinct UL24 promoters by regulatory proteins of equine herpesvirus type 1 (EHV-1). FEBS Lett. 2015 Jun 4;589(13):1467-75. doi: 10.1016/j.febslet.2015.04.039. Epub 2015 May 1. PMID: 25937123
20.Du C, Ma J, Liu Q, Li YF, He XJ, Lin YZ, Wang XF, Meng QW, Wang X*, Zhou JH*. Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection. Retrovirology. 2015 Apr 28;12:36. doi: 10.1186/s12977-015-0163-7. PMID: 25928027 Free PMC Article
21.C. Du, H. Liu, Y. Lin, X. Wang, J. Ma, Y. Li, X. Wang*, J. Zhou*. Proteomic alteration of equine monocyte-derived macrophages infected with equine infectious anemia virus. Proteomics, 2015, online. DOI: 10.1002/pmic.201400279
22.Tang YD, Na L, Fu LH, Yang F, Zhu CH, Tang L, Li Q, Wang JY, Li Z, Wang XF, Li CY, Wang X*, Zhou JH*. Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity. Virology. 2015 Jan 9;476C:364-371. doi: 10.1016/j.virol.2014.12.038. [Epub ahead of print] PubMed PMID: 25589239.
23.Wang XF, Wang S, Liu Q, Lin YZ, Du C, Tang YD, Na L, Wang X*, Zhou JH*. A unique evolution of the s2 gene of equine infectious anemia virus in hosts correlated with particular infection statuses. Viruses. 2014 Nov 10;6(11):4265-79. doi: 10.3390/v6114265. PubMed PMID: 25390683.
24.Hu Z, Chang H, Ge M, Lin Y, Wang X, Guo W, Wang X*. Development of antigen capture ELISA for the quantification of EIAV p26 protein. Appl Microbiol Biotechnol. 2014 Nov;98(21):9073-81. doi: 10.1007/s00253-014-6078-8. Epub 2014 Sep 26. PubMed PMID: 25256618.
25.Tang YD, Na L, Zhu CH, Shen N, Yang F, Fu XQ, Wang YH, Fu LH, Wang JY, Lin YZ, Wang XF, Wang X, Zhou JH, Li CY. Equine Viperin Restricts Equine Infectious Anemia Virus Replication by Inhibiting the Production and/or Release of Viral Gag, Env, and Receptor via Distortion of the Endoplasmic Reticulum. J Virol. 2014 Nov 1;88(21):12296-310. doi: 10.1128/JVI.01379-14. Epub 2014 Aug 13. PubMed PMID: 25122784.
26.Ai Y, Zhu D, Wang C, Su C, Ma J, Ma J, Wang X*. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. J Virol. 2014 Oct;88(20):12112-22. doi: 10.1128/JVI.01924-14. Epub 2014 Aug 13. PubMed PMID: 25122780;
27.Ma J, Wang SS, Lin YZ, Liu HF, Liu Q, Wei HM, Wang XF, Wang YH, Du C, Kong XG, Zhou JH, Wang X*. Infection of equine monocyte-derived macrophages with an attenuated equine infectious anemia virus (EIAV) strain induces a strong resistance to the infection by a virulent EIAV strain. Vet Res. 2014 Aug 9;45:82. doi: 10.1186/PREACCEPT-1630367192112621. PubMed PMID: 25106750.
28.Yin X, Hu Z, Gu Q, Wu X, Zheng YH, Wei P, Wang X*. Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein. J Virol. 2014 Jan;88(2):1259-70.
29.Hu Z, Zhu C, Chang H, Guo W, Liu D, Xiang W, Wang X*. Development of a single-tube duplex EvaGreen real-time PCR for the detection and identification of EHV-1 and EHV-4. Appl Microbiol Biotechnol. 2014 May;98(9):4179-86. doi: 10.1007/s00253-014-5626-6. Epub 2014 Mar 11. PubMed PMID: 24615388.
30.Na L, Tang YD, Liu JD, Yu CQ, Sun LK, Lin YZ, Wang XF, Wang X*, Zhou JH*. TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque negatively modulates TRIM5α activity. Biochem Biophys Res Commun. 2014 Apr 4;446(2):470-4. doi: 10.1016/j.bbrc.2014.02.132. Epub 2014 Mar 12. PubMed PMID: 24613845.
31.Wang M, Guo W, Igarashi I, Xuan X, Wang X, Xiang W, Jia H. Epidemiological investigation of equine piroplasmosis in China by enzyme-linked immunosorbent assays. J Vet Med Sci. 2014 Apr;76(4):549-52.
32.Yin X, Lin Y, Cai W, Wei P, Wang X*. Comprehensive analysis of the overall codon usage patterns in equine infectious anemia virus. Virol J. 2013 Dec 20;10:356. doi: 10.1186/1743-422X-10-356. PubMed PMID: 24359511; PubMed Central PMCID: PMC3878193.
33.Wang M, Guo W, Igarashi I, Xuan X, Wang X, Xiang W, Jia H. Epidemiological investigation of equine piroplasmosis in China by enzyme-linked immunosorbent assays. J Vet Med Sci. 2014 Apr;76(4):549-52. Epub 2013 Nov 29. PubMed PMID: 24292247;
34.Hu Z, Wu X, Ge J, Wang X*. Inhibition of virus replication and induction of human tetherin gene expression by equine IFN-α1. Vet Immunol Immunopathol. 2013 Nov 15;156(1-2):107-13. doi: 10.1016/j.vetimm.2013.09.009. Epub 2013 Sep 20. PubMed PMID: 24144682.
35.Wang Q, Ji X, Gao Y, Qi X, Wang X, Wang Y, Qin L, Gao H, Wang X*. Overexpression of microRNA gga-miR-1650 decreases the replication of avian leukosis virus subgroup J in infected cells. J Gen Virol. 2013 Oct;94(Pt 10):2287-96. doi: 10.1099/vir.0.054007-0. Epub 2013 Aug 1. PubMed PMID: 23907393.
36.Lu G, Guo W, Qi T, Ma J, Zhao S, Tian Z, Pan J, Zhu C, Wang X, Xiang W. Genetic analysis of the PB1-F2 gene of equine influenza virus. Virus Genes. 2013 Oct;47(2):250-8. doi: 0.1007/s11262-013-0935-x. Epub 2013 Jun 19. PubMed PMID:23780220.
37.Liu C, Guo W, Lu G, Xiang W, Wang X *. Complete genomic sequence of an equine herpesvirus type 8 Wh strain isolated from China. J Virol. 2012 May;86(9):5407. doi: 10.1128/JVI.00445-12. PubMed PMID: 22492929; PubMed Central PMCID: PMC3347380.
38.Wei L, Fan X, Lu X, Zhao L, Xiang W, Zhang X, Xue F, Shao Y, Shen R *, Wang X *. Genetic variation in the long terminal repeat associated with the transition of Chinese equine infectious anemia virus from virulence to avirulence. Virus Genes. 2009 Apr;38(2):285-8. doi: 10.1007/s11262-008-0317-y. Epub 2009 Jan 7. PubMed PMID: 19130201.
39.Abudu A, Wang X, Dang Y, Zhou T, Xiang SH, Zheng YH. Identification of molecular determinants from Moloney leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-HIV-1 activity. J Biol Chem. 2012 Jan 6;287(2):1220-8. doi: 10.1074/jbc.M111.309831. Epub 2011 Nov 21. PubMed PMID: 22105071;
40.Wang X, Abudu A, Son S, Dang Y, Venta PJ, Zheng YH. Analysis of human APOBEC3H haplotypes and anti-human immunodeficiency virus type 1 activity. J Virol. 2011 Apr;85(7):3142-52. doi: 10.1128/JVI.02049-10. Epub 2011 Jan 26. PubMed PMID: 21270145; PubMed Central PMCID: PMC3067873.
41.Dang Y, Wang X, York IA, Zheng YH. Identification of a critical T(Q/D/E)x5ADx2(I/L) motif from primate lentivirus Vif proteins that regulate APOBEC3G and APOBEC3F neutralizing activity. J Virol. 2010 Sep;84(17):8561-70. doi: 10.1128/JVI.00960-10. Epub 2010 Jun 30. PubMed PMID: 20592083
42.Wang X, Han Y, Dang Y, Fu W, Zhou T, Ptak RG, Zheng YH. Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication. J Biol Chem. 2010 May 7;285(19):14346-55. doi: 10.1074/jbc.M110.109314. Epub 2010 Mar 9. PubMed PMID：20215113; PubMed Central PMCID: PMC2863248.
43.Dang Y, Wang X, Zhou T, York IA, Zheng YH. Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralization. J Virol. 2009 Sep;83(17):8544-52. doi: 10.1128/JVI.00651-09. Epub 2009 Jun 17. PubMed PMID: 19535447; PubMed Central PMCID: PMC2738151.
44.Zhou T, Han Y, Dang Y, Wang X, Zheng YH. A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR. Retrovirology. 2009 Apr 3;6:31. doi: 10.1186/1742-4690-6-31. PubMed PMID: 19344514; PubMed Central PMCID: PMC2676246.
45.Han Y, Wang X, Dang Y, Zheng YH. Demonstration of a novel HIV-1 restriction phenotype from a human T cell line. PLoS One. 2008 Jul 30;3(7):e2796. doi:10.1371/journal.pone.0002796. PubMed PMID: 18665212; PubMed Central PMCID: PMC2464712.
46.Han Y, Wang X, Dang Y, Zheng YH. APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication. PLoS Pathog. 2008 Jul 4;4(7):e1000095. doi: 10.1371/journal.ppat.1000095. PubMed PMID: 18604271; PubMed Central PMCID: PMC2435275.
47.Dang Y, Siew LM, Wang X, Han Y, Lampen R, Zheng YH. Human cytidine deaminase APOBEC3H restricts HIV-1 replication. J Biol Chem. 2008 Apr 25;283(17):11606-14. doi: 10.1074/jbc.M707586200. Epub 2008 Feb 25. PubMed PMID: 18299330; PubMed Central PMCID: PMC2430661.
48.Wang X, Dolan PT, Dang Y, Zheng YH. Biochemical differentiation of APOBEC3F and APOBEC3G proteins associated with HIV-1 life cycle. J Biol Chem. 2007 Jan 19;282(3):1585-94. Epub 2006 Dec 1. PubMed PMID: 17142455; PubMed Central PMCID: PMC1880894.
49.Dang Y, Wang X, Esselman WJ, Zheng YH. Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family. J Virol. 2006 Nov;80(21):10522-33. Epub 2006 Aug 18. Erratum in: J Virol. 2011 May;85(10):5243. PubMed PMID: 16920826; PubMed Central PMCID: PMC1641744.
50.Tao Zhou, Xiufang Yuan, Shaohua Hou, Yabin Tu, Jinmei Peng, Jianxin Wen, Huaji Qiu, Donglai Wu, Huanchun Chen, Xiaojun Wang *, Guangzhi Tong *. Long terminal repeat sequences from virulent and attenuated equine infectious anemia virus demonstrate distinct promoter activities. Virus Res. 2007 Sep; 128(1-2):58-64.
51.马流感，学术专着，动物疫病防控出版工程，中国农业出版社，ISBN:9787109210158，230千字，2015年12月出版。
52.马传染性贫血，学术专着，动物疫病防控出版工程，中国农业出版社，ISBN:9787109206618，200千字，2015年12月出版。
53.默克兽医手册，学术专着，动物疫病防控出版工程，中国农业出版社，ISBN:9787109207509，4112千字，2015年12月出版。
54.现代动物病毒学，学术专着，中国农业出版社，ISBN:9787109197435，2783千字，2014年12月出版。
55.动物病毒反向遗传学，学术专着，生命科学专论，科学出版社，ISBN:9787030420718，883千字，2009年2月出版。
7、专利和标准
(1)王晓钧，胡哲。一种可抑制病毒粒子释放的蛋白，其编码序列及在抑制EIAV从细胞释放中的应用，2014年9月，中国，ZL201210535066.1。
(2)王晓钧，胡哲。一种用于检测I型和IV型马疱疹病毒的双重EVAGREEN实时荧光定量PCR检测试剂盒及其应用。2014年9月，中国，ZL201410042034.7。
(3)王晓钧，胡哲，林跃智，周建华。用于检测马传染性贫血病毒P26蛋白的试剂盒及其用途。2014年5月，中国，ZL201410239152.7。
(4)王晓钧。分泌SAMHD1蛋白单克隆抗体的杂交瘤细胞株、由该细胞株分泌的单克隆抗体及应用。2012年12月，中国，ZL201210535066.1。
(5)马传染性贫血病毒代表毒株的全基因克隆极其应用。1999年12月，ZL99127532.2。
8、获得奖励
(1)国家“万人计划”中青年科技创新领军人才，2016年
(2)哈尔滨市青年科技奖，2016年
(3)中国农业科学院2014-2015年度先进工作者
(4)科技部中青年科技创新领军人才，2014年
(5)中国农业科学院金龙鱼杰出青年奖，2014年
(6)首届国家国家自然基金委优秀青年基金获得者，2012年
(7)中国马流感病毒分离株分离鉴定及病毒进化的研究，中国农科院科技成果奖, 二等奖，2011-2-10-04，2011年，第四名
(8)无规定马属动物疫病区模式建立与应用研究, 广州市科技进步奖，一等奖, 2012年，第十名
(9)我国马流感病毒不同分离株生物学特征的研究,中国农科院科技进步二等奖，2004年（第四名）
(10)我国马流感病毒不同分离株生物学特征的研究,哈尔滨市科技进步三等奖2004年（第四名）
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