1、个人简历
李慧昕,女,博士,副研究员,硕士生导师,禽呼吸道病团队,骨干专家二级。一直从事禽病毒性呼吸道病研究工作,包括禽腺病毒流行病学及致病机制研究、传染性喉气管炎流行病学研究以及重组鸭瘟病毒疫苗载体研究等。主持国家重点研发计划课题1项、国家自然科学基金1项、省部级项目和自主研究课题2项,参加国家科技支撑项目和现代农业产业技蛋鸡术体系等国家级项目2项。参编论着2部,参译论着1部,在国内外核心期刊上发表论文50余篇,其中SCI检索论文26篇。获农业部中华农业科技优秀创新团队奖(等同于科研成果一等奖)1项,国家发明专利授权3项,实用新型专利2项;培养硕士研究生11名。
2、联系方式
(1)研究方向:兽医微生物及其分子生物学
(2)电话:13796659845
(3)邮箱:lihuixin@caas.cn
(4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号 保定市金诺兽药研究所 邮编:150069
3、教育经历
1996年9月-2001年7月,东北农业大学,动物医学专业,获学士学位
2001年9月-2004年7月,东北农业大学,预防兽医学专业,获硕士学位
2009年9月-2012年7月,中国农业科学院研究生院,获博士学位
4、工作经历
2007年7月-2010年12月,保定市金诺兽药研究所,助理研究员
2011年1月-至今,保定市金诺兽药研究所,副研究员
5、承担项目
(1)“十三五” 国家重点研发计划项目:畜禽重要疫病流行病学数据库和传播风险评估模型构建(2017YFD0500105,2017.07-2020.12),330万元,主持;
(2)国家自然基金项目:血清4型禽腺病毒3'端135-bp自然缺失影响病毒致病性的研究(31702268,2018.01-2020.12),24万元,主持;
(3)兽医生物技术国家重点实验室基本科研业务费,禽呼吸道病毒遗传变异规律及其机制研究,(SKLVBP2015008,2015.01-2017.12),85万元,主持;
(4)基本科研业务费:禽腺病毒血清4型变异株分子流行病学研究及血清学调查,(1610302017003,2017.01-2017.12),46万元,主持;
(5)蛋鸡科技创新体系项目:蛋鸡疫病综合防控,(CARS-41-K12,2016.01-2019.12),350万元,参加;
(6)国家科技支撑计划课题:禽流感等重要家禽疫病流行毒疫苗研究与开发,(2015BAD12B03,2015.01-2019.12),690万元,参加。
6、代表论文与着作
1)Huixin Li, Juan Wang, Liye Qiu, Zongxi Han, Shengwang Liu. Fowl adenovirus species C serotype 4 is attributed to the emergence of hepatitis-hydropericardium syndrome in chickens in China. Infect Genet Evol. 2016, 45:230-241.
2)Huixin Li#, Yulong Wang#, Zongxi Han, Yu Wang, Shulin Liang, Lu Jiang, Yonghao Hu, Xiangang Kong, Shengwang Liu*. Recombinant duck enteritis viruses expressing major structural proteins of the infectious bronchitis virus provide protection against infectious bronchitis in chickens[J]. Antiviral Res. 2016,130:19-26.
3)Jia Lin#, Huixin Li#, Jun Xia, Xuenan Li, Xiuqing Jiang, Shiyong Zhu, Jing Ge, Jinlong Li The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: modulation of ionic homeostasis. Sci Rep. 2016, 6:24855 (Coauthor)
4)Hai Li , Fengjie Wang , Zongxi Han, Qi Gao, Huixin Li, Yuhao Shao, Nana Sun and Shengwang Liu*. Genome-wide gene expression analysis identifies the proto-oncogene tyrosine-protein kinase Src as a crucial virulence determinant of the infectious laryngotracheitis virus in chicken cells[J]. Journal of Virology, 2016, 90(1):9-21.
5)Qianqian Xu, Zongxi Han, Qiuling Wang, Tingting Zhang, Mengying Gao, Yan Zhao, Yuhao Shao, Huixin Li, Xiangang Kong, Shengwang Liu*. Emergence of novel nephropathogenic infectious bronchitis viruses currently circulating in Chinese chicken flocks[J]. Avian Pathol. 2016,45(1):54-65.
6)Zongxi Han, Tingting Zhang, Qianqian Xu, Mengying Gao, Yuqiu Chen, Qiuling Wang, Yan Zhao, Yuhao Shao, Huixin Li, Xiangang Kong, Shengwang Liu*, Altered pathogenicity of a tl/CH/LDT3/03 genotype infectious bronchitis coronavirus due to natural recombination in the 5′- 17 kb region of the genome[J]. Virus Research,Virus Research,2016,213:140-148.
7)Tingting Zhang, Zongxi Han, Qianqian Xu, Qiuling Wang, Mengying Gao, Wei Wu, Yuhao Shao, Huixin Li, Xiangang Kong, Shengwang Liu*. Serotype shift of a 793/B genotype infectious bronchitis coronavirus by natural recombination[J]. Infection, Genetics and Evolution, 2015,32:377–387.
8)Wei Wu, Huairan Liu, Tingting Zhang, Zongxi Han , Yanyu Jiang , Qianqian Xu , Yuhao Shao, Huixin Li, Xiangang Kong, Hongyan Chen , Shengwang Liu*. Molecular and antigenic characteristics of Newcastle disease virus isolates from domestic ducks in China[J]. Infection, Genetics and Evolution, 2015,32:34–43.
9)Qianqian Xu, Zongxi Han, Qiuling Wang, Tingting Zhang, Mengying Gao, Yan Zhao, Yuhao Shao, Huixin Li, Xiangang Kong , Shengwang Liu*, Emergence of Novel Nephropathogenic Infectious Bronchitis Viruses Currently Circulating in Chinese Chicken Flocks[J]. Avian Pathology. 2015, 9:1-37.
10)Shengwang Liu*, Qianqian Xu, Zongxi Han, Xiaoli Liu, Huixin Li, Hongbo Guo, Nana Sun, Yuhao Shao, Xiangang Kong. Origin and characteristics of the recombinant novel avian infectious bronchitis coronavirus isolate ck/CH/LJL/111054[J]. Infection, Genetics and Evolution, 2014, 23:189-195.
11)Jinlong Li#, Huixin Li#, Shu Li, Zhihui Jiang, Shiwen Xu, Zhaoxin Tang. Selenoprotein W gene expression in the gastrointestinal tract of chicken is affected by dietary selenium. Biometals. 2011, 24(2):291-299.
12)Huixin Li, Shengwang Liu, Zongxi Han, Yuhao Shao, Shuhong Chen, and Xiangang Kong. Comparative analysis of the genes UL1 through UL7 of the duck enteritis virus and other herpesviruses of the subfamily Alphaherpesvirinae[J]. Genetics and Molecular Biology. 2009, 32:121-128.
13)Huixin Li, Shengwang Liu and Xiangang Kong. Characterization of the genes encoding UL24, TK and gH proteins from duck enteritis virus (DEV): a proof for the classification of DEV[J]. Virus Genes, 2006, 33, 221-227.
14)《兽医病毒学》(第二版),中国农业出版社,2017,参译。
15)《高级动物免疫学》(第一版),科学出版社,2017,参编。
7、专利和标准
专利:
(1)刘胜旺,李慧昕,韩宗玺,孔宪刚,表达增强型绿色荧光蛋白基因的鸭瘟病毒重组疫苗株及其构建方法和应用,2017.01.18,中国,ZL201410330828.3
(2)刘胜旺,孔宪刚,韩宗玺,邵昱昊,李慧昕. 鸡传染性支气管炎病毒弱毒疫苗株及其应用,2011.3,中国,ZL200910128488.5
(3)李金龙,李慧昕,徐世文,赵连彬,李楠,曹嫦妤,王丽丽,一种用于预防与治疗新生仔猪腹泻中和郑的药物组合物,2015.08.05,中国,ZL201310125373.7
标准:
(1) 刘胜旺,李慧昕,韩宗玺,王娟,邵昱昊,农业行业标准《产蛋下降综合征诊断技术》,NY/T 551-2017。
8、获得奖励
新型禽用疫苗与诊断试剂创制创新团队,获得中华农业科技奖优秀创新团队奖,王笑梅、刘胜旺、王云峰、刘长军、高玉龙、祁小乐、秦立廷、高宏雷、韩宗玺、邵昱昊、刘晓丽、李慧昕、张艳萍、李志杰、崔红玉、赵妍、王永强,2013年。