1、个人简历

    王永强，男，博士，副研究员，导师陈化兰院士，禽免疫抑制病研究团队，青年骨干。主要从事传染性法氏囊病等禽免疫抑制病病原学、免疫学及分子生物学方面的研究。在传染性法氏囊病病毒（IBDV）与宿主相互作用研究中取得重要进展，揭示了自噬内体系统协助病毒蛋白成熟和膜介导子代病毒粒子释放的机制；揭示了宿主蛋白VDAC1通过增强RNPs复合体的稳定性从而促进聚合酶活性进而增强病毒复制的机制。在国际着名病毒学杂志《Journal of Virology》发表SCI文章2篇；以第一或通讯作者发表SCI文章12篇。主持国家自然科学基金青年项目1项，主持黑龙江省自然科学基金优秀青年项目1项，参与国家自然科学基金重点项目1项，获国家发明专利2项；参译着作1部；获省市奖2项。协助首席培养多名博士与硕士研究生。

 

2、联系方式    

（1）研究方向：兽医微生物及其分子生物学

（2）电话：13804511635

（3）邮箱：wangyongqiang@caas.cn

（4）所在单位：保定市金诺兽药研究所

（5）通讯地址：哈尔滨市香坊区哈平路678号

 

3、教育经历

2002.09-2006.06  四川农业大学    生物技术    理学学士

2006.09-2009.06  中国农业科学院  预防兽医学  农学硕士

2011.09-2017.06  甘肃农业大学/中国农业科学院    预防兽医学    农学博士

 

4、工作经历

2009.07-2012.12   保定市金诺兽药研究所   研究实习员

2013.01-2017.12   保定市金诺兽药研究所   助理研究员

2018.01-至今        保定市金诺兽药研究所   副研究员

 

5、承担项目

   1. 国家自然科学基金青年项目：J亚群禽白血病病毒3’非编码区自然缺失205bp影响病毒致病性的研究（31201923，2013.01-2015.12），23万元；

   2. 黑龙江省自然科学基金优秀青年项目：钙离子感受器STIM1影响传染性法氏囊病超强毒复制的作用机制（YQ2019C029，2019.07-2022.07），10万元。

 

6、代表论文与着作

1. Han Chunyan, Niu Xinxin, Liu Lanlan, Li Jiukuan, Li Jing, Yao Shuai, Song Xiuqing, Gao Honglei, Gao Yulong, Qi Xiaole, Zeng Xiangwei, Wang Yongqiang*, Wang Xiaomei*. Development of a loop-mediated isothermal amplification assay for the detection of chicken anemia virus. Poultry Science. 2019, 98:1176-1180.

2. Yao Shuai, Tuo Tianbei, Gao Xiang, Han Chunyan, Yan Nana, Liu Aijing, Gao Honglei, Gao Yulong, Cui Hongyu, Liu Changjun, Zhang Yanping, Qi Xiaole, Hussain A, Wang Yongqiang*, Wang Xiaomei*. Molecular epidemiology of chicken anaemia virus in sick chickens in China from 2014 to 2015. PLoS One. 2019 Jan 18;14(1):e0210696.

3. Han Chunyan, Zeng Xiangwei, Yao Shuai, Gao Li, Zhang Lizhou, Qi Xiaole, Duan Yulu, Yang Bo, Gao Yulong, Liu Changjun, Zhang Yanping, Wang Yongqiang*, Wang Xiaomei*. Voltage-dependent anion channel 1 interacts with ribonucleoprotein complexes to enhance infectious bursal disease virus polymerase activity. Journal of Virology. 2017 Jul 27;91(16). pii: e00584-17.

4. Wang Yongqiang, Duan Yulu, Han Chunyan, Yao Shuai, Qi Xiaole, Gao Yulong, Maier HJ, Britton P, Chen Lei, Zhang Lizhou, Gao Li, Gao Honglei, Shen Nan, Wang Jingfei, Wang Xiaomei*. Infectious Bursal Disease Virus Subverts Autophagic Vacuoles To Promote Viral Maturation and Release. Journal of Virology. 2017 Feb 14;91(5). pii: e01883-16.

5. Wang Yongqiang^#, Song Xiuqing^#, Gao Honglei, Wang Xiaoyan, Hu Yonghao, Gao Yulong, Qi Xiaole, Qin Liting, Lin Huan, Gao Li, Yao Shuai, Han Chunyan, Wang Xiaomei, Chen Hualan*. C-terminal region of apoptin affects chicken anemia virus replication and virulence. Virology Journal. 2017 Feb 21;14(1):38.

6. Yao Shuai, Gao Xiang, Tuo Tianbei, Han Chunyan, Gao Yulong, Qi Xiaole, Zhang Yanping, Liu Changjun, Gao Honglei, Wang Yongqiang*, Wang Xiaomei*. Novel characteristics of the avian gyrovirus 2 genome. Scientific Reports. 2017 Feb 15;7:41068.

7. Yao Shuai, Tuo Tianbei, Gao Xiang, Han Chunyan, Li You, Gao Yulong, Zhang Yanping, Liu Changjun, Qi Xiaole, Gao Honglei, Wang Yongqiang*, Wang Xiaomei*. Avian gyrovirus 2 in poultry, China, 2015-2016. EMERGING MICROBES & INFECTIONS. 2016 Oct 26;5(10):e112.

8. Wang Qi, Gao Yulong, Ji Xiaolin, Qi Xiaole, Qin Liting, Gao Honglei, Wang Yongqiang*, Wang Xiaomei*. Differential expression of microRNAs in avian leukosis virus subgroup J-induced tumors. Veterinary Microbiology. 2013 Feb 22;162(1):232-238.

9. Wang Yongqiang, Kang Zhonghui, Gao Honglei, Gao Yulong, Qin Liting, Lin Huan, Yu Fei, Qi Xiaole, Wang Xiaomei*. A one-step reverse transcription loop-mediated isothermal amplification for detection and discrimination of infectious bursal disease virus. Virology Journal. 2011 Mar 8;8:108.

10. Wang Yongqiang, Kang Zhonghui, Gao Yulong, Qin Liting, Chen Lei, Wang Qi, Li Jiukuan, Gao Honglei, Qi Xiaole, Lin Huan, Wang Xiaomei*. Development of loop-mediated isothermal amplification for rapid detection of avian leukosis virus subgroup A. Journal of Virological Methods. 2011 Apr;173(1):31-36.

11. Wang Yongqiang^#, Qi Xiaole^#, Kang Zhonghui, Yu Fei, Qin Liting, Gao Honglei, Gao Yulong, Wang Xiaomei*. A single amino acid in the C-terminus of VP3 protein influences the replication of attenuated infectious bursal disease virus in vitro and in vivo. Antiviral Research. 2010 Aug;87(2):223-229.

12. Wang Yongqiang, Qi Xiaole, Gao Honglei, Gao Yulong, Lin Huan, Song Xiuqing, Pei Lei, Wang Xiaomei*. Comparative study of the replication of infectious bursal disease virus in DF-1 cell line and chicken embryo fibroblasts evaluated by a new real-time RT-PCR. Journal of Virological Methods. 2009 May;157(2):205-210.

 

7、专利和标准

   1.  王笑梅，王永强，高玉龙，高宏雷，秦立廷，祁小乐，检测A亚群禽白血病病毒的环介导等温扩增反应引物，ZL201010528610.0

   2.  王笑梅，王永强，高宏雷，高玉龙，秦立廷，祁小乐，检测B亚群禽白血病的环介导等温扩增反应引物，ZL201010528615.3

 

8、获得奖励

1. 禽白血病综合防控技术及应用，哈尔滨市科技进步二等奖，高玉龙，王笑梅，孙刚，王永强，王牟平，张永国，郎景华，朱海波，祁小乐，2016年

2. 禽重要免疫抑制病防控关键技术创制与应用，黑龙江省科技进步一等奖，王笑梅，高玉龙，刘长军，祁小乐，张艳萍，高宏雷，王永强，王牟平，李海燕，张连祥，高立，2018年

 

（2019年6月更新）