1、个人简历
郭龙军,男,博士,副研究员,猪消化道传染病团队,主要从事猪腹泻病毒等基础免疫学研究。近年来以第一作者发表SCI论文6篇,其中Journal of Virology 论文3篇;主持国家自然科学基金项目及黑龙江省自然科学基金各一项;主持中国农业科学院优秀青年引导项目一项,参与国家自然科学基金项目、黑龙江省自然科学基金等项目多项。
2、联系方式
(1)研究方向:兽医微生物及其分子生物学
(2)电话:0451-51051715
(3)邮箱:guolongjun@caas.cn
(4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号
3、教育经历
2003.09-2007.06 青岛农业大学 动物医学专业 学士
2007.09-2012.06 保定市金诺兽药研究所 预防兽医学专业 博士
4、工作经历
2012.07-2012.12 中国农科院哈尔滨兽医研究所 研究实习员
2013.01-2016.12 中国农科院哈尔滨兽医研究所 助理研究员
2017.01-至今 中国农科院哈尔滨兽医研究所 副研究员
5、承担项目
1. 国家自然科学基金青年科学基金项目:细胞自噬对猪传染性胃肠炎病毒感染的抑制作用研究(31500128,2016.01-2018.12),25万元;
2. 中国农业科学院优秀青年引导项目:猪流行性腹泻病毒(PEDV)抑制Ⅰ型干扰素产生的分子机制研究(Y2017JC05,2017.01-2019.12),60万元;
3. 黑龙江省自然科学基金项目:猪源金属蛋白酶ADAM17对PEDV感染的抑制作用研究(QC2014C038,2016.07-2017.06),5万元。
6、代表论文与着作
1. Longjun Guo, Junwei Niu, Haidong Yu, Weihong Gu, Ren Li, Xiaolei Luo, Mingming Huang, Zhijun Tian, Li Feng, Yue Wang*. Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry. Journal of Virology. 2014, 88(18): 10448-10458.
2. Longjun Guo, Xiaolei Luo, Ren Li, Yunfei Xu, Jian Zhang, Jinying Ge, Zhigao Bu, Li Feng, Yue Wang*. Porcine epidemic diarrhea virus infection inhibits interferon signaling by targeted degradation of STAT1. Journal of Virology. 2016, 90(18): 8281-8292.
3. Xiaolei Luo#, Longjun Guo#, Jian Zhang, Yunfei Xu, Weihong Gu, Li Feng, Yue Wang*. Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor. Journal of Virology. 2017, 91(10): 00202-00217. (Co-first author)
4. Longjun Guo, Haidong Yu, Weihong Gu, Xiaolei Luo, Ren Li, Jian Zhang, Yunfei Xu, Lijun Yang, Nan Shen, Li Feng, Yue Wang*. Autophagy negatively regulates transmissible gastroenteritis virus replication. Scientific Reports. 2016, 6:23864.
5. Jian Zhang#, Longjun Guo#, Lijun Yang, Jiayu Xu, Lu Zhang, Li Feng, Hongyan Chen, Yue Wang. Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N. Virology. 2018,517:24-29. (Co-first author)
6. Weihong Gu#, Longjun Guo#, Ren Li, Junwei Niu, Xiaolei Luo, Jian Zhang, Yunfei Xu, Zhijun Tian, Li Feng, Yue Wang*. Elevated plasma-soluble CD16 levels in porcine reproductive and respiratory syndrome virus-infected pigs: correlation with ADAM17-mediated shedding. Journal of General Virology. 2016, 97(3): 632-638. (Co-first author)
7. Longjun Guo, Yujie Fu, Liping Huang, Yiping Wang, Yanwu Wei, Hongli Wu, Changming Liu*. A commercial PCV2a-based vaccine is effective in protection from experimental challenge of PCV2 mutant with two amino acids elongation in capsid protein. Vaccine. 2015, 33(31): 3752-3757.
8. Weihong Gu, Longjun Guo, Haidong Yu, Junwei Niu, Mingming Huang, Xiaolei Luo, Ren Li, Zhijun Tian, Li Feng, Yue Wang*. Involvement of CD16 in antibody-dependent enhancement of porcine reproductive and respiratory syndrome virus infection. Journal of General Virology. 2015, 96: 1712-1722.
9. Ren Li, Longjun Guo, Weihong Gu, Xiaolei Luo, Jian Zhang, Yunfei Xu, Zhijun Tian, Li Feng, Yue Wang*. Production of porcine TNFalpha by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection. Immunologic Research. 2016, 64(3): 711-720.
10. Jian Zhang, Longjun Guo, Yunfei Xu, Lijun Yang, Hongyan Shi, Li Feng*, Yue Wang*. Characterization of porcine epidemic diarrhea virus infectivity in human embryonic kidney cells. Archives of Virology. 2017, 162(8): 2415-2419.
7、获得奖励
1. 猪圆环病毒病防控关键技术创新与应用,中国农业科学院科学技术成果一等奖,刘长明,危艳武,陆月华,张超范,黄立平,郭龙军,2013年。
2. 猪圆环病毒2型灭活疫苗产业化开发与推广应用,全国农牧渔业丰收奖二等奖,刘长明,危艳武,陆月华,张超范,黄立平,郭龙军,曲乃昌,刘全胜,成体鸽,陈连和,王云龙,郑新平,闫恒普,耿鸿霜,朱庸康,马平,杨瑞华,顾叶明,李文革,2013年。
3. 猪圆环病毒疫苗及配套诊断技术的研究与产业化,中华农业科技奖三等奖,刘长明,危艳武,陆月华,张超范,黄立平,郭龙军,2013年。
(2019年6月更新)